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Name | 5-hydroxytryptamine receptor 1A |
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Species | Homo sapiens (Human) |
Gene | HTR1A |
Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
Length | 422 |
Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
UniProt | P08908 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08908 |
3D structure model | This predicted structure model is from GPCR-EXP P08908. |
BioLiP | N/A |
Therapeutic Target Database | T78709 |
ChEMBL | CHEMBL214 |
IUPHAR | 1 |
DrugBank | BE0000291 |
Name | CHEMBL3342858 |
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Molecular formula | C24H32N4O3 |
IUPAC name | 3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-8-pyridin-2-yl-1,4-dioxa-8-azaspiro[4.5]decane |
Molecular weight | 424.545 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 2.9 |
Synonyms | BDBM50099442 |
Inchi Key | FHQARSACZPJNBL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H32N4O3/c1-29-22-7-3-2-6-21(22)27-16-14-26(15-17-27)18-20-19-30-24(31-20)9-12-28(13-10-24)23-8-4-5-11-25-23/h2-8,11,20H,9-10,12-19H2,1H3 |
PubChem CID | 118716705 |
ChEMBL | CHEMBL3342858 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Emax | 41.0 % | PMID25261823 | ChEMBL |
Ki | 8.913 nM | PMID25261823 | ChEMBL |
pD2 | 6.49 - | PMID25261823 | ChEMBL |
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