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GPCR

NameFree fatty acid receptor 4
SpeciesRattus norvegicus (Rat)
GeneFfar4
Synonymomega-3 fatty acid receptor 1
O3FAR1
GT01
GPR129
GPR120
[ Show all ]
DiseaseN/A for non-human GPCRs
Length361
Amino acid sequenceMSPECAQTTGPGPSRTPDQVNRTHFPFFSDVKGDHRLVLSVLETTVLGLIFVVSLLGNVCALVLVVRRRRRGATVSLVLNLFCADLLFTSAIPLVLVVRWTEAWLLGPVVCHLLFYVMTMSGSVTILTLAAVSLERMVCIVRLRRGLSGPGRRTQAALLAFIWGYSALAALPLCILFRVVPQRLPGGDQEIPICTLDWPNRIGEISWDVFFVTLNFLVPGLVIVISYSKILQITKASRKRLTLSLAYSESHQIRVSQQDYRLFRTLFLLMVSFFIMWSPIIITILLILIQNFRQDLVIWPSLFFWVVAFTFANSALNPILYNMSLFRSEWRKIFCCFFFPEKGAIFTETSIRRNDLSVIST
UniProtQ2AC31
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3309099
IUPHAR127
DrugBankN/A

Ligand

NameGSK137647A
Molecular formulaC16H19NO3S
IUPAC name4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular weight305.392
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.5
Synonyms349085-82-1
4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide
4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
AC1LEYMC
AJ-292/14925630
[ Show all ]
Inchi KeyFQUAFMNPXPXOJE-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
PubChem CID743974
ChEMBLCHEMBL3311308
IUPHARN/A
BindingDB50044849
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50794.0 nMPMID24881566BindingDB
EC50794.33 nMPMID24881566ChEMBL
Rmax100.0 %PMID24881566ChEMBL

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