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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 41
Species	Homo sapiens (Human)
Gene	TAS2R41
Synonym	T2R41 T2R59 TAS2R41 Taste receptor type 2 member 59 taste receptor, type 2, member 41
Disease	N/A
Length	307
Amino acid sequence	MQAALTAFFVLLFSLLSLLGIAANGFIVLVLGREWLRYGRLLPLDMILISLGASRFCLQLVGTVHNFYYSAQKVEYSGGLGRQFFHLHWHFLNSATFWFCSWLSVLFCVKIANITHSTFLWLKWRFPGWVPWLLLGSVLISFIITLLFFWVNYPVYQEFLIRKFSGNMTYKWNTRIETYYFPSLKLVIWSIPFSVFLVSIMLLINSLRRHTQRMQHNGHSLQDPSTQAHTRALKSLISFLILYALSFLSLIIDAAKFISMQNDFYWPWQIAVYLCISVHPFILIFSNLKLRSVFSQLLLLARGFWVA
UniProt	P59536
Protein Data Bank	N/A
GPCR-HGmod model	P59536
3D structure model	This predicted structure model is from GPCR-EXP P59536.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309108
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GSK137647A
Molecular formula	C16H19NO3S
IUPAC name	4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular weight	305.392
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	N-mesityl-4-methoxy-1-benzenesulfonamide SR-01000478738-1 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide AS-16737 CHEMBL3311308 GSK137647A, >=98% (HPLC) KB-3356964 Oprea1_349531 ZINC184126 AC1LEYMC BDBM50044849 EX-A1097 MFCD02007969 SMSF0014079 AKOS003261220 CBMicro_012617 GSK-137647A N-mesityl-4-methoxybenzenesulfonamide ST50719559 4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide B7793 CS-5549 HY-19995 KS-00000TIW Oprea1_545891 [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine AJ-292/14925630 BIM-0012523.P001 FT-0700296 MolPort-000-626-674 SR-01000478738 349085-82-1 AOB2991 NCGC00387253-02 STK899558 BCP17136 EU-0076636 J-690285 MCULE-5583867808 SCHEMBL19357604 AK240703 CB15818 GSK 137647 [ Show all ]
Inchi Key	FQUAFMNPXPXOJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
PubChem CID	743974
ChEMBL	CHEMBL3311308
IUPHAR	N/A
BindingDB	50044849
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<50118.7 nM	PMID24881566	ChEMBL
EC50	>50119.0 nM	PMID24881566	BindingDB

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