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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 88
Species	Homo sapiens (Human)
Gene	GPR88
Synonym	GPR88 STRG striatum-specific G-protein coupled receptor
Disease	N/A
Length	384
Amino acid sequence	MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProt	Q9GZN0
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZN0
3D structure model	This predicted structure model is from GPCR-EXP Q9GZN0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3399910
IUPHAR	123
DrugBank	N/A

Ligand

Name	CHEMBL3403781
Molecular formula	C25H36N2O2
IUPAC name	(2S)-N-[(1R)-2-(dimethylamino)-1-[4-(2-methylpentoxy)phenyl]ethyl]-2-phenylpropanamide
Molecular weight	396.575
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.5
Synonyms	BDBM50064752 SCHEMBL2519787
Inchi Key	HIRRPDKPLQSEIP-LZJVKYBRSA-N
Inchi ID	InChI=1S/C25H36N2O2/c1-6-10-19(2)18-29-23-15-13-22(14-16-23)24(17-27(4)5)26-25(28)20(3)21-11-8-7-9-12-21/h7-9,11-16,19-20,24H,6,10,17-18H2,1-5H3,(H,26,28)/t19?,20-,24-/m0/s1
PubChem CID	51355032
ChEMBL	CHEMBL3403781
IUPHAR	N/A
BindingDB	50064752
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	29.0 nM	PMID25690789	BindingDB,ChEMBL
EC50	39.0 nM	None	ChEMBL

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