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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL3353524
Molecular formulaC27H31F3N2O4
IUPAC name4-[[1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carbonyl]-[[4-(trifluoromethyl)phenyl]methyl]amino]butanoic acid
Molecular weight504.55
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.2
SynonymsSCHEMBL11302343
BDBM50032350
Inchi KeyIISRXBZYWKGMAS-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H31F3N2O4/c1-18-13-19(2)15-21(14-18)16-23(33)32-12-10-26(32,3)25(36)31(11-4-5-24(34)35)17-20-6-8-22(9-7-20)27(28,29)30/h6-9,13-15H,4-5,10-12,16-17H2,1-3H3,(H,34,35)
PubChem CID70559021
ChEMBLCHEMBL3353524
IUPHARN/A
BindingDB50032350
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50551.0 nMPMID25380412BindingDB,ChEMBL

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