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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400150
Molecular formulaC29H34N2O2
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-2-(4-methoxyphenyl)-N-(4-phenylphenyl)cyclopropane-1-carboxamide
Molecular weight442.603
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.5
SynonymsBDBM50065739
Inchi KeyJGNZNLKZPHNXEW-JQAQQEILSA-N
Inchi IDInChI=1S/C29H34N2O2/c1-4-20(2)28(30)19-31(24-14-10-22(11-15-24)21-8-6-5-7-9-21)29(32)27-18-26(27)23-12-16-25(33-3)17-13-23/h5-17,20,26-28H,4,18-19,30H2,1-3H3/t20-,26-,27+,28+/m0/s1
PubChem CID118727620
ChEMBLCHEMBL3400150
IUPHARN/A
BindingDB50065739
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<25000.0 nMPMID25754495BindingDB,ChEMBL

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