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GPCR

NameD(3) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD3
Synonymdopaminergic receptor D3
D3R
D3 receptor
dopamine D3 receptor
DiseaseUnspecified
Emesis; Gastric motility disorder
Female sexual dysfunction
Male sexual disorders
Psychotic disorders
[ Show all ]
Length400
Amino acid sequenceMASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProtP35462
Protein Data Bank3pbl
GPCR-HGmod modelP35462
3D structure modelThis structure is from PDB ID 3pbl.
BioLiPBL0191566, BL0191567
Therapeutic Target DatabaseT02551
ChEMBLCHEMBL234
IUPHAR216
DrugBankBE0000581

Ligand

NameCHEMBL538977
Molecular formulaC23H26N4O3
IUPAC name3-(3-nitrophenyl)-5-[4-(4-phenylpiperazin-1-yl)butyl]-1,2-oxazole
Molecular weight406.486
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP4.5
Synonyms1-{4-[3-(3-Nitro-phenyl)-isoxazol-5-yl]-butyl}-4-phenyl-piperazine; hydrochloride
BDBM50112798
SCHEMBL6768248
3-(3-Nitrophenyl)-5-[4-(4-phenylpiperazino)butyl]isoxazole
CHEMBL1189537
Inchi KeyAFTMDSQMJPSVNL-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H26N4O3/c28-27(29)21-10-6-7-19(17-21)23-18-22(30-24-23)11-4-5-12-25-13-15-26(16-14-25)20-8-2-1-3-9-20/h1-3,6-10,17-18H,4-5,11-16H2
PubChem CID22727351
ChEMBLN/A
IUPHARN/A
BindingDB50112798
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki60.0 nMPMID11992769BindingDB

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