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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400244
Molecular formulaC26H30N2O2
IUPAC name(1R,2R)-N-[(2S)-2-amino-4-methylpentyl]-N-[4-(furan-3-yl)phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight402.538
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.6
SynonymsBDBM50065705
Inchi KeyJMVBTBCTKLACNO-ZKMPZPQNSA-N
Inchi IDInChI=1S/C26H30N2O2/c1-18(2)14-22(27)16-28(23-10-8-19(9-11-23)21-12-13-30-17-21)26(29)25-15-24(25)20-6-4-3-5-7-20/h3-13,17-18,22,24-25H,14-16,27H2,1-2H3/t22-,24-,25+/m0/s1
PubChem CID118727653
ChEMBLCHEMBL3400244
IUPHARN/A
BindingDB50065705
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC502000.0 nMPMID25754495BindingDB,ChEMBL

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