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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL68167
Molecular formulaC27H41N7O5
IUPAC nametert-butyl N-[4-[2-(1H-imidazol-5-yl)ethylamino]pentanoylamino]-N-[1-[[2-(methylamino)-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Molecular weight543.669
Hydrogen bond acceptor7
Hydrogen bond donor5
XlogP1.7
SynonymsN/A
Inchi KeyKEVKUIQZOLROBW-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H41N7O5/c1-19(30-14-13-21-16-29-18-32-21)11-12-23(35)33-34(26(38)39-27(2,3)4)22(15-20-9-7-6-8-10-20)25(37)31-17-24(36)28-5/h6-10,16,18-19,22,30H,11-15,17H2,1-5H3,(H,28,36)(H,29,32)(H,31,37)(H,33,35)
PubChem CID44307251
ChEMBLCHEMBL68167
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency0.0 -PMID2959777ChEMBL

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