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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400248
Molecular formulaC29H34N2O
IUPAC name(1R,2R)-N-[(2S)-2-amino-4-methylpentyl]-N-[4-(4-methylphenyl)phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight426.604
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.9
SynonymsBDBM50065701
Inchi KeyLKCJTJRKSCHVCC-RZDMPUFOSA-N
Inchi IDInChI=1S/C29H34N2O/c1-20(2)17-25(30)19-31(29(32)28-18-27(28)24-7-5-4-6-8-24)26-15-13-23(14-16-26)22-11-9-21(3)10-12-22/h4-16,20,25,27-28H,17-19,30H2,1-3H3/t25-,27-,28+/m0/s1
PubChem CID118727657
ChEMBLCHEMBL3400248
IUPHARN/A
BindingDB50065701
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50360.0 nMPMID25754495BindingDB,ChEMBL

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