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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400206
Molecular formulaC29H34N2O
IUPAC name(1R,2R)-N-[2-(2-methylbutylamino)ethyl]-2-phenyl-N-(4-phenylphenyl)cyclopropane-1-carboxamide
Molecular weight426.604
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.0
SynonymsBDBM50065745
Inchi KeyLOAALDUKVGAKKL-LPRJAOSGSA-N
Inchi IDInChI=1S/C29H34N2O/c1-3-22(2)21-30-18-19-31(29(32)28-20-27(28)25-12-8-5-9-13-25)26-16-14-24(15-17-26)23-10-6-4-7-11-23/h4-17,22,27-28,30H,3,18-21H2,1-2H3/t22?,27-,28+/m0/s1
PubChem CID118727614
ChEMBLCHEMBL3400206
IUPHARN/A
BindingDB50065745
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC504.7 nMPMID25754495BindingDB,ChEMBL

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