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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL573284 |
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Molecular formula | C18H21N5O2 |
IUPAC name | 4-[(1R)-1-cyclopropylethyl]-6-[(6-methoxy-2,5-dimethylpyridin-3-yl)amino]-5-oxopyrazine-2-carbonitrile |
Molecular weight | 339.399 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 1.9 |
Synonyms | BDBM50300141 (R)-4-(1-Cyclopropylethyl)-6-(6-methoxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile |
Inchi Key | CLRRTXABLKAYGU-GFCCVEGCSA-N |
Inchi ID | InChI=1S/C18H21N5O2/c1-10-7-15(11(2)20-17(10)25-4)22-16-18(24)23(9-14(8-19)21-16)12(3)13-5-6-13/h7,9,12-13H,5-6H2,1-4H3,(H,21,22)/t12-/m1/s1 |
PubChem CID | 44596702 |
ChEMBL | CHEMBL573284 |
IUPHAR | N/A |
BindingDB | 50300141 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 10.0 nM | PMID19954247 | BindingDB,ChEMBL |
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