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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 88
Species	Homo sapiens (Human)
Gene	GPR88
Synonym	GPR88 STRG striatum-specific G-protein coupled receptor
Disease	N/A
Length	384
Amino acid sequence	MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProt	Q9GZN0
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZN0
3D structure model	This predicted structure model is from GPCR-EXP Q9GZN0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3399910
IUPHAR	123
DrugBank	N/A

Ligand

Name	CHEMBL3401460
Molecular formula	C30H37N3O2
IUPAC name	(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-N-[4-(4-propan-2-yloxyphenyl)phenyl]-2-pyridin-2-ylcyclopropane-1-carboxamide
Molecular weight	471.645
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	BDBM50065916 LZUIELTTXOOADX-RFNYNIMXSA-N (1R,2R)-2-pyridin-2-yl-cyclopropanecarboxylic acid ((2S,3S)-2-amino-3-methyl-pentyl)-(4'-isopropoxy-biphenyl-4-yl)-amide SCHEMBL2516828
Inchi Key	LZUIELTTXOOADX-RFNYNIMXSA-N
Inchi ID	InChI=1S/C30H37N3O2/c1-5-21(4)28(31)19-33(30(34)27-18-26(27)29-8-6-7-17-32-29)24-13-9-22(10-14-24)23-11-15-25(16-12-23)35-20(2)3/h6-17,20-21,26-28H,5,18-19,31H2,1-4H3/t21-,26+,27+,28+/m0/s1
PubChem CID	51348672
ChEMBL	CHEMBL3401460
IUPHAR	N/A
BindingDB	50065916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.0 nM	None	ChEMBL
EC50	3.5 nM	PMID25754495	BindingDB,ChEMBL

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