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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL3353000
Molecular formulaC23H27ClN2O2
IUPAC nameN-[(4-chlorophenyl)methyl]-1-[2-(3,5-dimethylphenyl)acetyl]-N,2-dimethylazetidine-2-carboxamide
Molecular weight398.931
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.1
SynonymsSCHEMBL15383315
BDBM50032308
Inchi KeyMBBVGWVPFHDCQH-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27ClN2O2/c1-16-11-17(2)13-19(12-16)14-21(27)26-10-9-23(26,3)22(28)25(4)15-18-5-7-20(24)8-6-18/h5-8,11-13H,9-10,14-15H2,1-4H3
PubChem CID89900321
ChEMBLCHEMBL3353000
IUPHARN/A
BindingDB50032308
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501434.0 nMPMID25380412BindingDB,ChEMBL

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