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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 88
Species	Homo sapiens (Human)
Gene	GPR88
Synonym	GPR88 STRG striatum-specific G-protein coupled receptor
Disease	N/A
Length	384
Amino acid sequence	MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProt	Q9GZN0
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZN0
3D structure model	This predicted structure model is from GPCR-EXP Q9GZN0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3399910
IUPHAR	123
DrugBank	N/A

Ligand

Name	CHEMBL3400203
Molecular formula	C29H34N2O
IUPAC name	(1R,2R)-N-[(3S)-3-amino-5-methylhexyl]-2-phenyl-N-(4-phenylphenyl)cyclopropane-1-carboxamide
Molecular weight	426.604
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.9
Synonyms	BDBM50065748
Inchi Key	MELKFMWFAZIFIP-FPNNDXFKSA-N
Inchi ID	InChI=1S/C29H34N2O/c1-21(2)19-25(30)17-18-31(29(32)28-20-27(28)24-11-7-4-8-12-24)26-15-13-23(14-16-26)22-9-5-3-6-10-22/h3-16,21,25,27-28H,17-20,30H2,1-2H3/t25-,27+,28-/m1/s1
PubChem CID	118727611
ChEMBL	CHEMBL3400203
IUPHAR	N/A
BindingDB	50065748
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.0 nM	PMID25754495	BindingDB
EC50	3.0 nM	PMID25754495	ChEMBL

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