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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400253
Molecular formulaC29H34N2O2
IUPAC name(1R,2R)-N-[(2S)-2-amino-4-methylpentyl]-N-[4-(2-methoxyphenyl)phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight442.603
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.5
SynonymsBDBM50065987
Inchi KeyMGVWFJODDNCWLB-MSLLRLGPSA-N
Inchi IDInChI=1S/C29H34N2O2/c1-20(2)17-23(30)19-31(29(32)27-18-26(27)21-9-5-4-6-10-21)24-15-13-22(14-16-24)25-11-7-8-12-28(25)33-3/h4-16,20,23,26-27H,17-19,30H2,1-3H3/t23-,26-,27+/m0/s1
PubChem CID118727662
ChEMBLCHEMBL3400253
IUPHARN/A
BindingDB50065987
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC503200.0 nMPMID25754495BindingDB,ChEMBL

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