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GPCR

NameAlpha-1B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1b
Synonymalpha1B-adrenoceptor
alpha1B-adrenergic receptor
alpha 1B-adrenoreceptor
alpha 1B-adrenoceptor
Alpha-1B adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length515
Amino acid sequenceMNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProtP15823
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL315
IUPHAR23
DrugBankN/A

Ligand

NameCHEMBL215151
Molecular formulaC24H26ClNO4
IUPAC nameN-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2-methoxy-6-phenylphenoxy)ethanamine;hydrochloride
Molecular weight427.925
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyAFUDWLGGLABPSJ-FYZYNONXSA-N
Inchi IDInChI=1S/C24H25NO4.ClH/c1-26-23-13-7-10-20(18-8-3-2-4-9-18)24(23)27-15-14-25-16-19-17-28-21-11-5-6-12-22(21)29-19;/h2-13,19,25H,14-17H2,1H3;1H/t19-;/m0./s1
PubChem CID11994664
ChEMBLCHEMBL215151
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Kd7.586 nMPMID17125266ChEMBL

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