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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cysteinyl leukotriene receptor 1
Species	Cavia porcellus (Guinea pig)
Gene	CYSLTR1
Synonym	CysLTR1 Cysteinyl leukotriene D4 receptor LTD4 receptor
Disease	N/A for non-human GPCRs
Length	340
Amino acid sequence	MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProt	Q2NNR5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5645
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL278920
Molecular formula	C26H24N2O5S
IUPAC name	N-(benzenesulfonyl)-4-[4-(quinolin-2-ylmethoxy)phenoxy]butanamide
Molecular weight	476.547
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM50013524 N-{4-[4-(Quinolin-2-ylmethoxy)-phenoxy]-butyryl}-benzenesulfonamide 4-[4-(2-Quinolylmethoxy)phenoxy]-N-phenylsulfonylbutyramide
Inchi Key	CLXLXWOOKSJSED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H24N2O5S/c29-26(28-34(30,31)24-8-2-1-3-9-24)11-6-18-32-22-14-16-23(17-15-22)33-19-21-13-12-20-7-4-5-10-25(20)27-21/h1-5,7-10,12-17H,6,11,18-19H2,(H,28,29)
PubChem CID	14650342
ChEMBL	CHEMBL278920
IUPHAR	N/A
BindingDB	50013524
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	31.0 nM	PMID2157009	BindingDB,ChEMBL

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