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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H2 receptor
Species	Mus musculus (Mouse)
Gene	Hrh2
Synonym	Gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProt	P97292
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2245
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL421482
Molecular formula	C17H24N4O
IUPAC name	4-[2-(1H-imidazol-5-yl)ethylamino]-N-(4-methylphenyl)pentanamide
Molecular weight	300.406
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.9
Synonyms	N/A
Inchi Key	PMHVAECKAAOWIJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H24N4O/c1-13-3-6-15(7-4-13)21-17(22)8-5-14(2)19-10-9-16-11-18-12-20-16/h3-4,6-7,11-12,14,19H,5,8-10H2,1-2H3,(H,18,20)(H,21,22)
PubChem CID	13974532
ChEMBL	CHEMBL421482
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Relative potency	0.0 -	PMID2959777	ChEMBL

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