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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide FF receptor 1
Species	Homo sapiens (Human)
Gene	NPFFR1
Synonym	GnIH-R G protein-coupled receptor 147 OT7T022 NPFF1R1 NPFF1 receptor NPFF1 G-protein coupled receptor 147 GPR147 GnIH-R/RFRP-3 RFamide-related peptide receptor OT7T022 [ Show all ]
Disease	N/A
Length	430
Amino acid sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProt	Q9GZQ6
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ6
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5951
IUPHAR	300
DrugBank	N/A

Ligand

Name	CHEMBL3360833
Molecular formula	C26H39N7O
IUPAC name	(2S)-2-amino-N-[[4-anilino-1-(2-phenylethyl)piperidin-4-yl]methyl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	465.646
Hydrogen bond acceptor	5
Hydrogen bond donor	5
XlogP	1.9
Synonyms	BDBM50029184
Inchi Key	SAFSCKKDYNYXHK-QHCPKHFHSA-N
Inchi ID	InChI=1S/C26H39N7O/c27-23(12-7-16-30-25(28)29)24(34)31-20-26(32-22-10-5-2-6-11-22)14-18-33(19-15-26)17-13-21-8-3-1-4-9-21/h1-6,8-11,23,32H,7,12-20,27H2,(H,31,34)(H4,28,29,30)/t23-/m0/s1
PubChem CID	118724539
ChEMBL	CHEMBL3360833
IUPHAR	N/A
BindingDB	50029184
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2906.0 nM	PMID25268943	BindingDB,ChEMBL

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