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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCID 44387393
Molecular formulaC143H233N37O40S
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-12-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-hydroxy-3,12-dioxododecan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3142.72
Hydrogen bond acceptor45
Hydrogen bond donor43
XlogP-8.6
SynonymsN/A
Inchi KeyCMKBZNIDAOEXQZ-OTCBGFOBSA-N
Inchi IDInChI=1S/C143H233N37O40S/c1-19-77(13)115(178-120(199)80(16)158-128(207)101(66-112(193)194)166-119(198)79(15)157-121(200)87(145)62-83-41-45-85(185)46-42-83)140(219)172-99(63-82-34-26-25-27-35-82)134(213)180-117(81(17)184)141(220)173-100(65-109(148)190)133(212)176-105(71-183)137(216)169-98(64-84-43-47-86(186)48-44-84)132(211)163-90(38-33-56-155-143(152)153)123(202)162-89(36-30-31-54-144)127(206)177-114(76(11)12)138(217)171-94(58-72(3)4)122(201)156-68-111(192)159-91(49-51-107(146)188)124(203)167-97(61-75(9)10)131(210)174-103(69-181)106(187)39-28-23-21-22-24-29-40-110(191)160-95(59-73(5)6)129(208)168-96(60-74(7)8)130(209)164-92(50-52-108(147)189)125(204)170-102(67-113(195)196)135(214)179-116(78(14)20-2)139(218)165-93(53-57-221-18)126(205)175-104(70-182)136(215)161-88(118(149)197)37-32-55-154-142(150)151/h25-27,34-35,41-48,72-81,87-105,114-117,181-186H,19-24,28-33,36-40,49-71,144-145H2,1-18H3,(H2,146,188)(H2,147,189)(H2,148,190)(H2,149,197)(H,156,201)(H,157,200)(H,158,207)(H,159,192)(H,160,191)(H,161,215)(H,162,202)(H,163,211)(H,164,209)(H,165,218)(H,166,198)(H,167,203)(H,168,208)(H,169,216)(H,170,204)(H,171,217)(H,172,219)(H,173,220)(H,174,210)(H,175,205)(H,176,212)(H,177,206)(H,178,199)(H,179,214)(H,180,213)(H,193,194)(H,195,196)(H4,150,151,154)(H4,152,153,155)/t77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,114-,115-,116-,117-/m0/s1
PubChem CID44387393
ChEMBLCHEMBL415372
IUPHARN/A
BindingDB50004977
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID1534126BindingDB,ChEMBL

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