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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesRattus norvegicus (Rat)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length468
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
UniProtQ7TQN8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5262
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3326667
Molecular formulaC21H25FN4O6S
IUPAC name(1-methylcyclopropyl) 4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate
Molecular weight480.511
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP2.6
SynonymsSCHEMBL13431747
1-Methylcyclopropyl 4-(5-Fluoro-6-(2-methyl-6-(methylsulfonyl)pyridin-3-yloxy)pyrimidin-4-yloxy)piperidine-1-carboxylate
TZEYAXGGRICVIJ-UHFFFAOYSA-N
BDBM50056004
Inchi KeyTZEYAXGGRICVIJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
PubChem CID66574514
ChEMBLCHEMBL3326667
IUPHARN/A
BindingDB50056004
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50169.0 nMPMID26048791, PMID25088191BindingDB,ChEMBL
Efficacy93.0 %PMID25088191ChEMBL
Emax93.0 %PMID26048791ChEMBL

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