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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuromedin-U receptor 2
Species	Homo sapiens (Human)
Gene	NMUR2
Synonym	G-protein coupled receptor FM-4 G-protein coupled receptor TGR-1 FM4 NMU-R2 NMU2 receptor FM-4 SNORF72 TGR-1 [ Show all ]
Disease	N/A
Length	415
Amino acid sequence	MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
UniProt	Q9GZQ4
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ4
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ4.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075144
IUPHAR	299
DrugBank	N/A

Ligand

Name	CHEMBL3343013
Molecular formula	C15H8ClFO3
IUPAC name	2-(3-chloro-2-fluorophenyl)-3-hydroxychromen-4-one
Molecular weight	290.674
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	1631715-09-7 BDBM50102654 4H-1-Benzopyran-4-one,2-(3-chloro-2-fluorophenyl)-3-hydroxy-
Inchi Key	VJYUBKKQQNPGAY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H8ClFO3/c16-10-6-3-5-9(12(10)17)15-14(19)13(18)8-4-1-2-7-11(8)20-15/h1-7,19H
PubChem CID	118716778
ChEMBL	CHEMBL3343013
IUPHAR	N/A
BindingDB	50102654
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	31100.0 nM	PMID25262941	BindingDB,ChEMBL

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