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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	dihydroisoquinolinone
Molecular formula	C25H41N3O2
IUPAC name	N-[2-(dimethylamino)ethyl]-N-[(3-methyl-1-oxo-2,4-dihydroisoquinolin-3-yl)methyl]decanamide
Molecular weight	415.622
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.1
Synonyms	CHEMBL1824269 SCHEMBL16948653 N-(2-dimethylaminoethyl)-N-[(3-methyl-1-oxo-2,4-dihydroisoquinolin-3-yl)methyl]decanamide
Inchi Key	WGLUNLJVYNJMBU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H41N3O2/c1-5-6-7-8-9-10-11-16-23(29)28(18-17-27(3)4)20-25(2)19-21-14-12-13-15-22(21)24(30)26-25/h12-15H,5-11,16-20H2,1-4H3,(H,26,30)
PubChem CID	56668956
ChEMBL	CHEMBL1824269
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1500.0 nM	PMID25052428	ChEMBL
EC50	1513.56 nM	PMID25052428	ChEMBL
Efficacy	-20.0 %	PMID25052428	ChEMBL

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