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GPCR

NameVasopressin V2 receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr2
SynonymAVPR V2
Antidiuretic hormone receptor
ADHR
Renal-type arginine vasopressin receptor
V2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length371
Amino acid sequenceMLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProtQ00788
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3766
IUPHAR368
DrugBankN/A

Ligand

NameCHEMBL437035
Molecular formulaC59H80N14O13S2
IUPAC name(2S)-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10S,13R,16S,19R,22S)-13-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-hydroxyphenyl)methyl]-23-methyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]pyrrolidine-2-carboxamide
Molecular weight1257.49
Hydrogen bond acceptor16
Hydrogen bond donor13
XlogP-0.6
SynonymsN/A
Inchi KeyCMVGBWLMQPTUQG-XPQVHIEFSA-N
Inchi IDInChI=1S/C59H80N14O13S2/c1-72-46(30-36-16-20-38(75)21-17-36)56(85)70-42(29-34-10-4-2-5-11-34)53(82)66-40(22-23-47(60)76)52(81)69-43(31-48(61)77)54(83)71-44(33-87-88-59(32-49(72)78)24-6-3-7-25-59)57(86)73-27-9-13-45(73)55(84)67-39(12-8-26-65-58(63)64)51(80)68-41(50(62)79)28-35-14-18-37(74)19-15-35/h2,4-5,10-11,14-21,39-46,74-75H,3,6-9,12-13,22-33H2,1H3,(H2,60,76)(H2,61,77)(H2,62,79)(H,66,82)(H,67,84)(H,68,80)(H,69,81)(H,70,85)(H,71,83)(H4,63,64,65)/t39-,40-,41-,42+,43+,44+,45-,46-/m0/s1
PubChem CID44350591
ChEMBLCHEMBL437035
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Effective dose63.0 nM kg-1PMID1531076ChEMBL
Kd6.0 nMPMID1531076ChEMBL

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