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GPCR

NameMas-related G-protein coupled receptor member X1
SpeciesMus musculus (Mouse)
GeneMrgprx1
SynonymMas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1
DiseaseN/A for non-human GPCRs
Length322
Amino acid sequenceMDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGNTIVLWLLGFRMRRKAISVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDILGNAAIIPYISGLSILSAISTERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGILDWFSGFLGETHHHLWKNVDFIITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYVTIALTVMVYLICGLPLGLYLFLLYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFLVGSFRQHRKHRSLKRVLKRALEDTPEEDEYTDSHLHKTTEISESRY
UniProtQ8CIP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3341576
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3343992
Molecular formulaC18H22N6O2
IUPAC name(2S)-2-[[2-amino-2-[3-(diaminomethylideneamino)phenyl]acetyl]amino]-3-phenylpropanamide
Molecular weight354.414
Hydrogen bond acceptor4
Hydrogen bond donor5
XlogP-0.3
SynonymsN/A
Inchi KeyYKCDVZGMEHGJGV-MLCCFXAWSA-N
Inchi IDInChI=1S/C18H22N6O2/c19-15(12-7-4-8-13(10-12)23-18(21)22)17(26)24-14(16(20)25)9-11-5-2-1-3-6-11/h1-8,10,14-15H,9,19H2,(H2,20,25)(H,24,26)(H4,21,22,23)/t14-,15?/m0/s1
PubChem CID118717466
ChEMBLCHEMBL3343992
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5031622.8 nMPMID25288495ChEMBL

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