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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | MLS003116585 |
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Molecular formula | C22H26N4O2S |
IUPAC name | (2R,4R,5R)-5-(4-cyclopropyltriazol-1-yl)-2-(4-methoxyphenyl)-1-(thiophen-2-ylmethyl)piperidin-4-ol |
Molecular weight | 410.536 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 2.5 |
Synonyms | NCGC00243096-01 KUC105109N SMR001832138 CHEMBL2143903 KUC105109 |
Inchi Key | AFXKNDHWOJNFSQ-YPAWHYETSA-N |
Inchi ID | InChI=1S/C22H26N4O2S/c1-28-17-8-6-16(7-9-17)20-11-22(27)21(14-25(20)12-18-3-2-10-29-18)26-13-19(23-24-26)15-4-5-15/h2-3,6-10,13,15,20-22,27H,4-5,11-12,14H2,1H3/t20-,21-,22-/m1/s1 |
PubChem CID | 46902622 |
ChEMBL | CHEMBL2143903 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Potency | 28183.8 nM | PubChem BioAssay data set | ChEMBL |
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