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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL3675881
Molecular formulaC29H23ClF3N3O3
IUPAC name3-[[5-[2-[[3-chloro-4-(2-fluoro-4-methylphenyl)anilino]methyl]-4,5-difluorophenyl]pyridine-2-carbonyl]amino]propanoic acid
Molecular weight553.966
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogP6.0
SynonymsSCHEMBL14056717
US8748624, 105
BDBM123602
Inchi KeyBGHFTCJPUSYILN-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H23ClF3N3O3/c1-16-2-5-21(24(31)10-16)20-6-4-19(12-23(20)30)35-15-18-11-25(32)26(33)13-22(18)17-3-7-27(36-14-17)29(39)34-9-8-28(37)38/h2-7,10-14,35H,8-9,15H2,1H3,(H,34,39)(H,37,38)
PubChem CID71060180
ChEMBLCHEMBL3675881
IUPHARN/A
BindingDB123602
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki33.0 nM, NoneBindingDB,ChEMBL

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