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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	SCHEMBL2587403
Molecular formula	C16H18N4O2
IUPAC name	3-(2-piperidin-1-yl-1,3-benzoxazol-6-yl)-4,5-dihydro-1H-pyridazin-6-one
Molecular weight	298.346
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.1
Synonyms	US8772323, 118 CHEMBL3901874 BDBM180617
Inchi Key	BPADYKARPZDBLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N4O2/c21-15-7-6-12(18-19-15)11-4-5-13-14(10-11)22-16(17-13)20-8-2-1-3-9-20/h4-5,10H,1-3,6-9H2,(H,19,21)
PubChem CID	67464658
ChEMBL	CHEMBL3901874
IUPHAR	N/A
BindingDB	180617
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3741.0 nM	, None	BindingDB,ChEMBL

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