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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3680842
Molecular formula	C34H27Cl2N3O3
IUPAC name	3-[[5-[2-[[4-(2,4-dichlorophenyl)anilino]methyl]-5-phenylphenyl]pyridine-2-carbonyl]amino]propanoic acid
Molecular weight	596.508
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	7.6
Synonyms	BDBM123650 SCHEMBL14054460 US8748624, 173
Inchi Key	BXMNNNWWYHFDLI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H27Cl2N3O3/c35-27-11-14-29(31(36)19-27)23-8-12-28(13-9-23)38-20-25-7-6-24(22-4-2-1-3-5-22)18-30(25)26-10-15-32(39-21-26)34(42)37-17-16-33(40)41/h1-15,18-19,21,38H,16-17,20H2,(H,37,42)(H,40,41)
PubChem CID	71059915
ChEMBL	CHEMBL3680842
IUPHAR	N/A
BindingDB	123650
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	27.0 nM	, None	BindingDB,ChEMBL

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