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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	VU0359455
Molecular formula	C21H24N4O3S
IUPAC name	3-amino-4-methyl-6-(2-morpholin-4-ylethoxy)-N-phenylthieno[2,3-b]pyridine-2-carboxamide
Molecular weight	412.508
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.6
Synonyms	3-amino-4-methyl-6-(2-morpholin-4-ylethoxy)-N-phenylthieno[2,3-b]pyridine-2-carboxamide 3-azanyl-4-methyl-6-(2-morpholin-4-ylethoxy)-N-phenyl-thieno[2,3-b]pyridine-2-carboxamide cid_45142489 3-amino-4-methyl-6-(2-morpholinoethoxy)-N-phenyl-thieno[2,3-b]pyridine-2-carboxamide 3-amino-4-methyl-6-[2-(4-morpholinyl)ethoxy]-N-phenyl-2-thieno[2,3-b]pyridinecarboxamide BDBM48078 [ Show all ]
Inchi Key	CGKOQKKSYUOXIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24N4O3S/c1-14-13-16(28-12-9-25-7-10-27-11-8-25)24-21-17(14)18(22)19(29-21)20(26)23-15-5-3-2-4-6-15/h2-6,13H,7-12,22H2,1H3,(H,23,26)
PubChem CID	45142489
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48078
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5810.0 nM	N/A	BindingDB

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