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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL136877
Molecular formula	C17H25NO2
IUPAC name	[4-[[1-(cyclopropylmethyl)piperidin-4-yl]methoxy]phenyl]methanol
Molecular weight	275.392
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.5
Synonyms	BDBM50002299 ZINC13730019 4-[[4-(Hydroxymethyl)phenoxy]methyl]-1-(cyclopropylmethyl)piperidine CHEMBL1180660 [4-(1-Cyclopropylmethyl-piperidin-4-ylmethoxy)-phenyl]-methanol;0.3hydrate
Inchi Key	DRHLUSIUCNGTDR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25NO2/c19-12-15-3-5-17(6-4-15)20-13-16-7-9-18(10-8-16)11-14-1-2-14/h3-6,14,16,19H,1-2,7-13H2
PubChem CID	10356045
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50002299
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID1360026	BindingDB

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