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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	C-C chemokine receptor-like 2
Species	Homo sapiens (Human)
Gene	CCRL2
Synonym	ACR5 CRAM-B CRAM-A CKRX Chemokine receptor X Chemokine receptor CCR11 CCRL2 CCR6 CCR11 Putative MCP-1 chemokine receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProt	O00421
Protein Data Bank	N/A
GPCR-HGmod model	O00421
3D structure model	This predicted structure model is from GPCR-EXP O00421.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2321627
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3704133
Molecular formula	C25H33F3N6O3
IUPAC name	tert-butyl N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]carbamate
Molecular weight	522.573
Hydrogen bond acceptor	10
Hydrogen bond donor	3
XlogP	4.0
Synonyms	BDBM163498 SCHEMBL12052205 US9062048, 125
Inchi Key	HAZIXYNHGMRKQR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H33F3N6O3/c1-24(2,3)37-23(36)33-16-5-7-18(8-6-16)34-12-17(13-34)32-21(35)11-29-22-19-10-15(25(26,27)28)4-9-20(19)30-14-31-22/h4,9-10,14,16-18H,5-8,11-13H2,1-3H3,(H,32,35)(H,33,36)(H,29,30,31)
PubChem CID	54769307
ChEMBL	CHEMBL3704133
IUPHAR	N/A
BindingDB	163498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	220.0 nM	, None	BindingDB,ChEMBL

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