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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 2
Species	Homo sapiens (Human)
Gene	LTB4R2
Synonym	NOP9 12-HHT receptor Seven transmembrane receptor BLTR2 LTB4-R2 LTB4-R 2 LTB4 receptor JULF2 Leukotriene B4 receptor BLT2 BLTR2 BLT2 receptor [ Show all ]
Disease	Inflammatory bowel disease
Length	358
Amino acid sequence	MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
UniProt	Q9NPC1
Protein Data Bank	N/A
GPCR-HGmod model	Q9NPC1
3D structure model	This predicted structure model is from GPCR-EXP Q9NPC1.
BioLiP	N/A
Therapeutic Target Database	T30563
ChEMBL	CHEMBL3191
IUPHAR	268
DrugBank	BE0003489

Ligand

Name	5-Hete
Molecular formula	C20H32O3
IUPAC name	(6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid
Molecular weight	320.473
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.2
Synonyms	1013AH 5-OH 6t,8c,11c,14c-20:4 CHEMBL17695 SR-01000946911-1 (+/-)5-HETE 5-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid 73307-52-5 KGIJOOYOSFUGPC-XTDASVJISA-N (6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid CC-00115 SCHEMBL2560910 HETE-(+/-)5 (6E,8Z,11Z,14Z)-5-hydroxy-6,8,11,14-eicosatetraenoic acid 5-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid BDBM50024447 LMFA03060084 (6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid 5-Hydroxy-icosa-6,8,11,14-tetraenoic acid CHEBI:60943 SR-01000946911 (+/-)-(6E,8Z,11Z,14Z)-5-Hydroxyeicosatetraenoic acid 5-hydroxy,6E,8Z,11Z,14Z-eicosatetraenoic acid 71030-39-2 HETE-5(S) (6E,8Z,11Z,14Z)-5-Hydroxy-icosa-6,8,11,14-tetraenoic acid 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid BML1-B02 NCGC00161236-01 [ Show all ]
Inchi Key	KGIJOOYOSFUGPC-XTDASVJISA-N
Inchi ID	InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+
PubChem CID	9862886
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50024447
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1000.0 nM	PMID11006272	BindingDB
Ki	3000.0 nM	PMID11006272	BindingDB

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