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GPCR

NameDelta-type opioid receptor
SpeciesSus scrofa (Pig)
GeneOPRD1
SynonymDOR-1
D-OR-1
DiseaseN/A for non-human GPCRs
Length228
Amino acid sequenceGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
UniProtP79291
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4103
IUPHARN/A
DrugBankN/A

Ligand

Namefentanyl
Molecular formulaC22H28N2O
IUPAC nameN-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Molecular weight336.479
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.0
SynonymsFentanil
Phentanyl
Fentora
Duragesic
Fentanest
[ Show all ]
Inchi KeyPJMPHNIQZUBGLI-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
PubChem CID3345
ChEMBLCHEMBL596
IUPHAR1626
BindingDB50008984
DrugBankDB00813

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki73.8 nMPMID9686407BindingDB

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