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GPCR

NameNeurotensin receptor type 2
SpeciesMus musculus (Mouse)
GeneNtsr2
SynonymNTRL
NTR2
NT2R
NT-R-2
neurotensin receptor type 2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length416
Amino acid sequenceMETSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
UniProtP70310
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR310
DrugBankN/A

Ligand

NameCabastine
Molecular formulaC26H29FN2O2
IUPAC name1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
Molecular weight420.528
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.5
Synonyms1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
79516-68-0
AC1L1GZW
BDBM85844
CAS_54385
[ Show all ]
Inchi KeyZCGOMHNNNFPNMX-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)
PubChem CID3915
ChEMBLN/A
IUPHARN/A
BindingDB85844
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki17.0 nMPMID11752130BindingDB

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