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GPCR

NameCannabinoid receptor 2
SpeciesHomo sapiens (Human)
GeneCNR2
SynonymPeripheral cannabinoid receptor
rCB2
hCB2
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)
[ Show all ]
DiseaseImmune disorder
Inflammatory bowel disease
Inflammatory disease
Neuropathic pain
Osteoporosis
[ Show all ]
Length360
Amino acid sequenceMEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProtP34972
Protein Data Bank5zty
GPCR-HGmod modelP34972
3D structure modelThis structure is from PDB ID 5zty.
BioLiPBL0438927
Therapeutic Target DatabaseT37693
ChEMBLCHEMBL253
IUPHAR57
DrugBankBE0000095

Ligand

NameCHEMBL3605035
Molecular formulaC20H14Cl2O3
IUPAC name[4-(3,5-dichlorophenyl)-3,5-dihydroxyphenyl]-(4-methylphenyl)methanone
Molecular weight373.229
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.8
SynonymsBDBM50111519
Inchi KeyADRQNADVLXKXGU-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H14Cl2O3/c1-11-2-4-12(5-3-11)20(25)14-8-17(23)19(18(24)9-14)13-6-15(21)10-16(22)7-13/h2-10,23-24H,1H3
PubChem CID122186208
ChEMBLCHEMBL3605035
IUPHARN/A
BindingDB50111519
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50118.0 nMPMID26275680BindingDB,ChEMBL
Efficacy230.0 %PMID26275680ChEMBL
Ki257.6 nMPMID26275680ChEMBL
Ki258.0 nMPMID26275680BindingDB

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