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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3604067
Molecular formulaC20H20F3NO4
IUPAC name(3S)-3-ethoxy-3-[6-[[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy]pyridin-3-yl]propanoic acid
Molecular weight395.378
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP3.5
SynonymsBDBM50114090
Inchi KeyAGMMSVUIVBGERN-SJORKVTESA-N
Inchi IDInChI=1S/C20H20F3NO4/c1-2-27-17(10-19(25)26)12-6-9-18(24-11-12)28-16-8-7-13-14(16)4-3-5-15(13)20(21,22)23/h3-6,9,11,16-17H,2,7-8,10H2,1H3,(H,25,26)/t16-,17+/m1/s1
PubChem CID122185452
ChEMBLCHEMBL3604067
IUPHARN/A
BindingDB50114090
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5020.0 nMPMID26234904BindingDB,ChEMBL

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