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GPCR

NameUrotensin-2 receptor
SpeciesHomo sapiens (Human)
GeneUTS2R
SynonymSENR (sensory epithelial neuropeptide-like receptor)
UII-R1
UT receptor
UR-2-R
UTR2
[ Show all ]
DiseaseAsthma
Diabetic nephropathy
Renal failure
Length389
Amino acid sequenceMALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProtQ9UKP6
Protein Data BankN/A
GPCR-HGmod modelQ9UKP6
3D structure modelThis predicted structure model is from GPCR-EXP Q9UKP6.
BioLiPN/A
Therapeutic Target DatabaseT49072
ChEMBLCHEMBL3764
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL189525
Molecular formulaC28H38Cl2N4O3
IUPAC name3,4-dichloro-N-[(2S)-1-[[(3S)-1-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]amino]-3-methyl-1-oxobutan-2-yl]benzamide
Molecular weight549.537
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.3
SynonymsN/A
Inchi KeyCNVZZZPLGYMSFV-NVQXNPDNSA-N
Inchi IDInChI=1S/C28H38Cl2N4O3/c1-19(2)26(32-27(35)21-8-11-24(29)25(30)16-21)28(36)31-22-12-14-34(18-22)17-20-6-9-23(10-7-20)37-15-5-13-33(3)4/h6-11,16,19,22,26H,5,12-15,17-18H2,1-4H3,(H,31,36)(H,32,35)/t22-,26-/m0/s1
PubChem CID12052413
ChEMBLCHEMBL189525
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki794.33 nMPMID15936190ChEMBL

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