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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL3686825
Molecular formulaC26H30N4O4
IUPAC name2-[2-[4-[[(2S,6S)-2-amino-6-methylmorpholin-4-yl]methyl]-2-methylphenyl]-2-oxoethyl]-5-phenylmethoxypyridazin-3-one
Molecular weight462.55
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP2.0
SynonymsBDBM142191
US8933079, 5.10
Inchi KeyAMWRHENRCKUIKV-DFBJGRDBSA-N
Inchi IDInChI=1S/C26H30N4O4/c1-18-10-21(14-29-13-19(2)34-25(27)16-29)8-9-23(18)24(31)15-30-26(32)11-22(12-28-30)33-17-20-6-4-3-5-7-20/h3-12,19,25H,13-17,27H2,1-2H3/t19-,25-/m0/s1
PubChem CID91759572
ChEMBLCHEMBL3686825
IUPHARN/A
BindingDB142191
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5035.0 nM, NoneBindingDB,ChEMBL

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