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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Homo sapiens (Human)
Gene	CRHR2
Synonym	CRH-R2 CRH-R-2 CRFR2beta CRFR2alpha CRFR2 CRFR-2 CRF2 receptor CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 [ Show all ]
Disease	Generalized anxiety disorder Anxiety disorder Congestive heart failure Eating disorders stimulate food consumption anxiety
Length	411
Amino acid sequence	MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q13324
Protein Data Bank	N/A
GPCR-HGmod model	Q13324
3D structure model	This predicted structure model is from GPCR-EXP Q13324.
BioLiP	N/A
Therapeutic Target Database	T11011
ChEMBL	CHEMBL4069
IUPHAR	213
DrugBank	N/A

Ligand

Name	195055-03-9
Molecular formula	C22H32N6
IUPAC name	3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Molecular weight	380.54
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.7
Synonyms	3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-n,n-dipropyl-pyrazolo[2,3-a]pyrimidine-7-amine ANNRUWYFVIGKHA-UHFFFAOYSA-N CHEMBL309138 KB-79289 R-121919 3-[6-(dimethylamino)-4-methylpyridin-3-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine AX8150177 DTXSID00173162 NBI 30775 TC-148159 [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-4H-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine 3-(6-(Dimethylamino);-4-methylpyridin-3-yl);-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine AB21702 CD-1823 GTPL3520 R 121919 3-[6-(dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[2,3-a]-pyrimidin-7-amine ANW-59414 CS-6231 KS-000006AG R121919 UNII-G82N555U1N 292073-75-7 BCP23964 FT-0767007 NBI-30775 [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine 3-(6-dimethylamino-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[5,1-b]pyrimidin-7-amine AKOS016002213 HY-14127 R-121,919 0092AB 3-[6-(dimethylamino)-4-methyl-pyrid-3-yl]-2,5-dimethyl-n,n-dipropyl-pyrazolo[2,3-a]pyrimidin-7-amine API0009338 CTK8B8151 MolPort-009-200-030 SCHEMBL5600844 ZINC602283 3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine BDBM50116105 G82N555U1N Pyrazolo(1,5-a)pyrimidin-7-amine, 3-(6-(dimethylamino)-4-methyl-3-pyridinyl)-2,5-dimethyl-n,N-dipropyl- [ Show all ]
Inchi Key	ANNRUWYFVIGKHA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
PubChem CID	9821250
ChEMBL	CHEMBL309138
IUPHAR	3520
BindingDB	50116105
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	23.8 %	PMID26456805	ChEMBL

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