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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL3586319
Molecular formula	C26H25NO3S
IUPAC name	7-(1-benzothiophen-3-yl)-9-methoxy-4-[(4-methoxyphenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepine
Molecular weight	431.55
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50092752
Inchi Key	APJHQPWHZVSVJO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H25NO3S/c1-28-21-9-7-18(8-10-21)15-27-11-12-30-26-20(16-27)13-19(14-24(26)29-2)23-17-31-25-6-4-3-5-22(23)25/h3-10,13-14,17H,11-12,15-16H2,1-2H3
PubChem CID	122180256
ChEMBL	CHEMBL3586319
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<30000.0 nM	PMID26061158	ChEMBL
IC50	1800.0 nM	PMID26061158	ChEMBL

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