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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	(+/-)-Epinephrine hydrochloride
Molecular formula	C9H14ClNO3
IUPAC name	[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium;chloride
Molecular weight	219.665
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	None
Synonyms	Epinephrine dl- hydrochloride [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylammonium chloride A821532 LS-42885 Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (+-)- MolPort-000-807-126 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride d-Epinephrine hydrochloride J-018951 [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium chloride (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride AC1L1T5P LS-42886 (1)-4-(1-Hydroxy-2-(methylamino)ethyl)pyrocatechol hydrochloride VC30860 4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE EINECS 206-346-0 KS-000017ZU [2-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-ethyl]-methyl-azanium chloride (+-)-Adrenaline hydrochloride BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((METHYLAMINO)METHYL)-, HYDROCHLORIDE, (+)- MCULE-9233286495 1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, hydrochloride CTK8F1536 [ Show all ]
Inchi Key	ATADHKWKHYVBTJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
PubChem CID	9489
ChEMBL	CHEMBL1255663
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	766.7 nM	PubChem BioAssay data set	ChEMBL

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