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Name | Metabotropic glutamate receptor 8 |
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Species | Homo sapiens (Human) |
Gene | GRM8 |
Synonym | mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor [ Show all ] |
Disease | N/A |
Length | 908 |
Amino acid sequence | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
UniProt | O00222 |
Protein Data Bank | 6bsz, 6bt5, 6e5v |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 6bsz. |
BioLiP | BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3228 |
IUPHAR | 296 |
DrugBank | BE0000835 |
Name | AC1N2AWG |
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Molecular formula | C24H24N2O4S |
IUPAC name | methyl 4-[3-[2-(4-acetamidophenyl)sulfanylacetyl]-2,5-dimethylpyrrol-1-yl]benzoate |
Molecular weight | 436.526 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.1 |
Synonyms | CHEMBL1585091 MolPort-005-870-139 731006-86-3 methyl 4-(3-(2-((4-acetamidophenyl)thio)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzoate VU0155094-5 [ Show all ] |
Inchi Key | BCNKQXDDMIBITO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H24N2O4S/c1-15-13-22(16(2)26(15)20-9-5-18(6-10-20)24(29)30-4)23(28)14-31-21-11-7-19(8-12-21)25-17(3)27/h5-13H,14H2,1-4H3,(H,25,27) |
PubChem CID | 4043841 |
ChEMBL | CHEMBL1585091 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 730.0 nM | PubChem BioAssay data set | ChEMBL |
EC50 | 930.0 nM | PubChem BioAssay data set | ChEMBL |
EC50 | 1800.0 nM | PubChem BioAssay data set | ChEMBL |
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