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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL3616585
Molecular formulaC36H34F3N3O4
IUPAC name3-[[4-[1-[3-[2-methoxy-5-(trifluoromethyl)phenyl]-7-(4-methylphenyl)indazol-1-yl]butyl]benzoyl]amino]propanoic acid
Molecular weight629.68
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP7.7
SynonymsBDBM50120282
Inchi KeyBGEYEXXYPCZGEW-UHFFFAOYSA-N
Inchi IDInChI=1S/C36H34F3N3O4/c1-4-6-30(24-13-15-25(16-14-24)35(45)40-20-19-32(43)44)42-34-27(23-11-9-22(2)10-12-23)7-5-8-28(34)33(41-42)29-21-26(36(37,38)39)17-18-31(29)46-3/h5,7-18,21,30H,4,6,19-20H2,1-3H3,(H,40,45)(H,43,44)
PubChem CID122189574
ChEMBLCHEMBL3616585
IUPHARN/A
BindingDB50120282
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50780.0 nMPMID26303893BindingDB,ChEMBL
IC503800.0 nMPMID26303893BindingDB,ChEMBL

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