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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
SynonymAdrenergic alpha2C- receptor class I
alpha-2C adrenoreceptor
alpha2-C4
Alpha-2CAR
alpha-2C adrenergic receptor
[ Show all ]
DiseasePoison intoxication
Hypotension
Male sexual disorders
Neurological disease
Obesity
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004888, BE0000342, BE0004864

Ligand

Name1-(3-Bromobenzyl)-1H-imidazole
Molecular formulaC10H9BrN2
IUPAC name1-[(3-bromophenyl)methyl]imidazole
Molecular weight237.1
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP2.3
Synonyms1-(3-bromobenzyl)-1H-imidazole, AldrichCPR
1-(3-bromobenzyl)imidazole
1-[(3-bromophenyl)methyl]-1H-imidazole
1-[(3-bromophenyl)methyl]imidazole
1H-Imidazole,1-[(3-bromophenyl)methyl]-
[ Show all ]
Inchi KeyBGYZLOIBJCHCTI-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H9BrN2/c11-10-3-1-2-9(6-10)7-13-5-4-12-8-13/h1-6,8H,7H2
PubChem CID10220337
ChEMBLCHEMBL598391
IUPHARN/A
BindingDB50307216
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<501187.0 nMPMID25648685ChEMBL
EC50>501187.0 nMPMID25648685BindingDB
Emax<105.0 %PMID25648685ChEMBL
Emax97.0 %PMID25648685ChEMBL
Ki1174.9 nMPMID25648685ChEMBL
Ki1175.0 nMPMID25648685BindingDB

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