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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3616647
Molecular formulaC15H12FNO4
IUPAC name2-(4-benzamido-2-fluorophenoxy)acetic acid
Molecular weight289.262
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.1
SynonymsN/A
Inchi KeyBHXKCRJKXWJWDK-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H12FNO4/c16-12-8-11(6-7-13(12)21-9-14(18)19)17-15(20)10-4-2-1-3-5-10/h1-8H,9H2,(H,17,20)(H,18,19)
PubChem CID122189667
ChEMBLCHEMBL3616647
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity3.56 %PMID26420383ChEMBL
Activity12.78 %PMID26420383ChEMBL

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