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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3616652
Molecular formulaC17H16FNO5
IUPAC name2-[2-fluoro-4-(2-phenoxypropanoylamino)phenoxy]acetic acid
Molecular weight333.315
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.9
SynonymsBDBM50120864
Inchi KeyBOUKLDZOFOGRSX-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H16FNO5/c1-11(24-13-5-3-2-4-6-13)17(22)19-12-7-8-15(14(18)9-12)23-10-16(20)21/h2-9,11H,10H2,1H3,(H,19,22)(H,20,21)
PubChem CID122189672
ChEMBLCHEMBL3616652
IUPHARN/A
BindingDB50120864
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity35.67 %PMID26420383ChEMBL
EC50135.0 nMPMID26420383BindingDB
EC50135.3 nMPMID26420383ChEMBL

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