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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 3
Species	Rattus norvegicus (Rat)
Gene	Grm3
Synonym	mGluR3 mGlu3 receptor GPRC1C glutamate receptor
Disease	N/A for non-human GPCRs
Length	879
Amino acid sequence	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	P31422
Protein Data Bank	2e4u, 2e4v, 2e4w, 2e4x, 2e4y
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2e4u.
BioLiP	BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3067
IUPHAR	291
DrugBank	N/A

Ligand

Name	CHEMBL3182491
Molecular formula	C24H25NO3
IUPAC name	(3-hydroxy-3-prop-2-enylpiperidin-1-yl)-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
Molecular weight	375.468
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.2
Synonyms	VU0475670-1
Inchi Key	BUHNJUNSVVBFTK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H25NO3/c1-3-15-24(27)16-4-17-25(18-24)23(26)21-11-7-19(8-12-21)5-6-20-9-13-22(28-2)14-10-20/h3,7-14,27H,1,4,15-18H2,2H3
PubChem CID	66577119
ChEMBL	CHEMBL3182491
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	783.06 nM	PubChem BioAssay data set	ChEMBL

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