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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
SynonymAdrenergic alpha2C- receptor class I
alpha-2C adrenoreceptor
alpha2-C4
Alpha-2CAR
alpha-2C adrenergic receptor
[ Show all ]
DiseasePoison intoxication
Hypotension
Male sexual disorders
Neurological disease
Obesity
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004888, BE0000342, BE0004864

Ligand

NameCHEMBL3590089
Molecular formulaC27H34N4O3
IUPAC name3'-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]spiro[2,3-dihydro-1H-naphthalene-4,5'-imidazolidine]-2',4'-dione
Molecular weight462.594
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.7
Synonyms1-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-3',4'-dihydrospiro[imidazolidine-4,1'(2'H)-naphthalene]-2,5-dione
BDBM50094283
Inchi KeyBUVAGKGIBHOSMY-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H34N4O3/c1-34-24-13-5-4-12-23(24)30-19-17-29(18-20-30)15-6-7-16-31-25(32)27(28-26(31)33)14-8-10-21-9-2-3-11-22(21)27/h2-5,9,11-13H,6-8,10,14-20H2,1H3,(H,28,33)
PubChem CID122181337
ChEMBLCHEMBL3590089
IUPHARN/A
BindingDB50094283
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity20.0 %PMID25936259ChEMBL
Inhibition79.0 %PMID25936259ChEMBL
Inhibition101.0 %PMID25936259ChEMBL

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